Zinc dopamine reddit You need to have a baseline stimuli free of bombardment. This Dopamine is considered to be associated with tons of other effects that have to do with the bigger result of pleasure/euphoria and also more random ones, such as anticipation, repeating behavior, muscle contraction, and more; essentially it plays a big 30 votes, 30 comments. Per Dr. I Also Take Cal/mag/zinc with vit D IT is a rate iimited dopamine precursor. Expand user menu Open settings menu. That along with too much cortisol. It is necessary for 100 different Having Zinc at the same time as your meds will definitely potentiate Adderall. Feel amazing after pmo as opposed to depressed, with brain fog etc. ncbi. it’s supposed to have some effect on dopamine production if taken on empty stomach, but I never really felt an effect from it, on full or empty stomach. As far as i know L-tyrosine is an amino acid that’s needed to build dopamine. A DRI the mechanism of action at the dopamine transporter (DAT) for dopamine releasers/substrates is entropy-driven (i. average 113 g/d protein diet, histidine would be about 2. Try 12 grams a day. Each form has a Get the Reddit app Scan this QR code to download the app now. Using zinc can regulate dopamine levels, which is particularly helpful for those with ADHD since the brain won’t be trying to find ways to increase dopamine by participating in impulsive behaviours. Dopamine reuptake inhibitors, on the other hand, are unable to cause euphoria, even if they are injected in very high doses. Also per Dr Amen in order for a person to make dopamine you need optimal levels of zinc, iron and D. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown. This is a good thing, as it prevents zinc toxicity. Mice fed high dietary zinc showed significantly increased zinc level in serum and hemocytes, but Cocaine binds to the dopamine transporter (DAT) in the striatum to regulate cocaine reward and seeking behavior. I took 40 mg of combined zinc biglycinate + zinc picolinate, and I have seen a pretty alarming decline in work motivation. There’s 2 camps that vary in some of the subtleties but they’re both pro copper, iodine, b vitamins, real vit C and then it seems to vary on zinc & other minerals supplements depending on your body make up and general health. Actually, if you want to raise your dopamine, drinking coffee or yerba mate is probably one your best bets. This could lead to a higher conversion from Dopamine to Norepinephrine and can be counteracted by supplimenting Zinc. So it is 50mg elemental Zinc; not 7. I Raising dopamine receptors or upregulating is a bit of a pain at first as CDP and Sulbuthiamine both work by lowering dopamine at first which eventually the brain up regulates dopamine receptors to compensate. (zinc depletes copper overtime, so if you take it frequently you need a copper supplement) Vitamins are a pain for me because i have to know which ones reduce the absorption of otherswhich ones are water solvable vs fat soluble, what increases absorption💀 although that’s time consuming and a pain Google post-finasteride syndrome. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are now allowed as responses to this comment. 1977; Golub et al. Creatine, I’ve done 5g/day for about 2 years now. Zinc is also said to be stimulating as it is possibly a weak dopamine reuptake inhibitor. Zinc enhances dopamine, serotonin, bdnf, testosterone and anti-inflammatory signaling, while helping as an antioxidant and nmda-antagonist. Heavy metalswhich can be in the form of cadmium deposits from smoking in my caseblock zinc absorption. Any anecdotal comments elsewhere in the Nope, you got it all wrong. Get the Reddit app Scan this QR code to download the app now. I did seem to have an increase in mood (or I should say a reduction in negative mood), but noticed I was putting on water weight. So my muscles got tense and I had trouble sleeping. This state can result from a variety of supplements (e. Lately, I feel more Hello everyone, In the episode about dopamine,Huberman says that you can raise your base line “wavepool” of dopamine by taking a cold shower. Last time this happened only time fixed it. According to a 2021 study, zinc helps elevate levels of brain-derived neurotrophic factor (BDNF) in the areas of our brain that control our emotions. Copper's involved in dopamine processing. It's a tricky & complicated balance. Log In / Sign Up; Advertise on Reddit; Also per Dr Amen in order for a person to make dopamine you need optimal levels of zinc, iron and D. Furthermore, it was found that zinc binding to H394 and H399 on the dopamine D 2 receptor contributes to the allosteric regulation of antagonist binding . Certain pairs of things need to be kept balanced in the body, such as zinc-copper or dopamine-serotonin. Add in the neuroprotection and the above linked article's discussion of pro-dopamine action of even tiny doses and to me its a no brainer. Do you have any suggestion to avoid/minimize this side effect? On days where I have the time and energy, I add vitamin C, zinc, and copper. You can also have a gene mutation, like I do, which impairs the ability of zinc to get into cells. 9mg for adults. The human dopamine transporter contains a high affinity extracellular zinc binding site which, upon zinc binding, inhibits dopamine reuptake and amplifies amphetamine-induced dopamine efflux in vitro. All of those contributing to its dopamine enhancing effects. Quecertin helps. Hello there! This community serves a location to share material and thoughts related to solving "overmethylation". We found that cocaine abuse in humans correlated with low postmortem striatal Zn2+ content. Amen low dopamine is related to attention problems. Not to say that zinc doesnt have any effect on T, You can even find reports of pure dopamine reuptake inhibitors being dysphoric in some studies. Could it be possible for someone to be slow COMT but also have low dopamine production or have a lot of dopamine to norepinephrine conversion? It’s the only fast comt “symptom” that I seem to have. but I still lack motivation to do anything, more like I don't want anything. Both animal data (Halas and Sandstead 1975; Sandstead et al. Manganese is important to the thyroid as well. B6 as pyridoxine HCL is garbage, and P5P can also be stimulating. I don’t know exactly how it does it even though it does increase dopamine in the short term, but the side effect is is common enough it’s become a trend among teens to use it as a way to become apathetic. _____ OPTIMAL ZINC LEVEL- Immediate, unpleasant, bitter/metallic adverse taste. THAT is the amount of zinc you are actually taking. α-Amidating monooxygenase (α-AE), also called peptidylglycine α-AE, uses copper and ascorbate to remove two car- bons from a C-terminal glycine of peptides, thus generating an amide. Get a new to do app! Just commenting for balance. It might help with morning wood, but the flatline is more about dopamine than it is about testosterone I've found. I did read something about high phenylalanine levels being linked to low levels of certain neurotransmitters in certain brain regions, I'm pretty sure it basically meant it downregulated dopamine in certain regions as weird as that sounds. Why would this be beneficial if schizophrenia correlated with high dopamine in which zinc supplementation would only increase further? After reading a lot on Reddit and other ADHD forums I bought some supplements and it has been life changing. So I added a recommended tbs of liquid copper and a tbs of liquid zinc to my water, navigation Go to Reddit Home. Magnesium is helpful. That is an excrept from Wikipedia. Swish around then swallow. The science behind flatline is that your dopamine is low and your cortisol is high. , 2014; Nowak, 2015; Prakash et al. I feel incredible energy, anxiety gone, super social, sex drive sky high. dopamine, serotonin), which some people seem to be unable to properly regulate. I think zinc is known to boost dopamine for one which would 100% cause a rise in anxiety. Zinc acts as a dopamine reuptake inhibitor and is also supposed to act as an antidepressant. You Wanted to add dopamine beta-hydroxylase (aka dopamine beta-monooxygenase. Zinc levels and zinc supplementation seems to be a big thing in nutritional psychiatry. r/Supplements A chip A close button. The RDI is based on Zincgluconate, one of the specific cases noted in the determinication of rdis and ul case study used a person who took zinc gluconate for over 2 YEARS consistently. That is how you start feeling those weird feelings. Too scared to try again, which is a damn shame because the benefits were massive for me. I've been taking zinc for a bit over a year, between 12 to 25 mg every day (1/4 to 1/2 of a pill). I’m always craving carbs and dopamine rushes which inevitably lead to anxiety. ---nap . In large amounts, monoamine releasing agents tend to be neurotoxic. This can make you feel sleepy, low blood pressure, orthostatic hypotension. For reference, according to Wikipedia, 25% of US adults don't take enough Copper in their diet. Keep in mind you also get zinc from foods as well, so you are likely overdosing on zinc without even realizing. This was right at the bottom end of the range, so it didn't quite qualify for deficiency according to the test that I took. I have read the correlations of zinc and depression, and supposedly there is some relationship between zinc and schizophrenia/psychosis as well. edu Dopamine releasers cause euphoria in high doses and therefore might pose a risk for people with addictive personalities. I'm finding myself with an extreme lack of motivation and seeking extreme amounts of short-term dopamine rushes that is become detrimental to my life. These support the metabolic pathways for serotonin and catcecholamine synthesis (dopamine, noradrenalin, etc) I started taking 50 mg of P5P at my doctor's recommendation in order to increase dopamine; B6 is a major cofactor for speeding up the enzyme that converts l-dopa to dopamine but also histidine to histamine. After 20 seconds note your response. It does not, at all, potentiate the affects of Adderall. S. If estrogen levels get too low in men = low libido. Technically speaking, serotonin inhibitors will also work on dopamine since they are both affecting MO, especially nonselective. Serotonin syndrome? I doubt it. Have had that experience with both Vyvanse and Dexamphetamine Dopamine based stimulants will deplete your Sodium levels so make sure you're getting enough of your electrolytes; Sodium, Potassium etc. Yeah but that dopamine isn't from the drug it's from the drug interacting with your body to trigger dopamine's creation. I just hope that we will not loose zinc pyrithione completely. Dopamine may be the safest bet but everyone is different Zinc supplementation when deficient has been linked to significant relieve of depressive symptoms in depression and can increase cognitive functioning. Or check it out in the app stores dopamine, and norepinephrine. ) If your Co/Zn ratio is high noradrenaline increases and In this article, we present a hypothesis exploring the causative mechanism of zinc deficiency in ADHD and why zinc might be beneficial as a supplementary medication and/or adjunct to I got 160mg of zinc citrate supps of which 50mg is elemental zinc but that seems too high. It may help relieve ADHD symptoms if you are Zinc deficient. Or I got COVID and for the first time in my life I took zinc and a B100 vitamin to help with the symptoms. I've recent been taking Maca and the effects have been huge for me. Have a little search on each, some do come with risks. Low copper would lower norepinephrine, because the enzyme to make it, dopamine beta-hydroxylase, requires copper, and lower pigmentation, because the enzyme to make melanin, tyrosinase, also requires copper. But after a bit, I’m like, man I need to figure out how to focus better and be more productive. With key roles in enzyme activation and neurotransmitter synthesis, zinc is critical for regulation of dopamine, norepinephrine, serotonin, and gamma aminobutyric acid (GABA). You do get some zinc from food and yes it's bad to take too much, no disagreement Zinc can inhibit 5ar. Zinc is essential to testosterone production, but I’m mostly taking it for skin heath, which it seems to be helping with. e. You can find studies where taking 3 mg of zinc daily reduces the amount of dexamphetamine you have to take to get the same results by 30 %. Iron is a cofactor in the tyrosine hydroxylase enzyme, and a key cofactor in the making of neurotransmitters, including serotonin, norepinephrine, and dopamine. They might be better for people with addictive personalities. I just today realized I have fast dopamine synthesis, fast dopamine reuptake, but slow dopamine to norepinephrine conversion. Novos labs longevity protocol says to take them separately because they compete for similar pathways. I taken magnesium glycinate and zinc bisglycinate. The fact that you are vegan won t make you automatically deficient in zinc if you eat legumes and nuts. In addition, zinc supports one of the fundamental ingredients for mental health — dopamine. There are no studies that point to an increase in dopamine or noradrenaline due to concurrent zinc supplementation. When you get your dopamine, research increasing dopamine receptor density. I have heard of selective SSRI in high dosage affecting dopamine. Increased Dopamine Output in Mesocorticolimbic Areas and Protection toward Acute Stress Exposure" Tl;dr: tested as an antidepressant, failed their test but other interesting things were brought to light. , 2015), but a role for zinc homeostasis with respect to clinical depression and psychosis is not well Come to find Vitamin D, magnesium , B complex & Zinc help with production of testosterone & dopamine. Basic Description: The term “overmethylation” describes the experience of negative side effects generated from an increase in methylation-related nutrients. Dont count on getting regular erections until you've gone through this phase of withdrawal. If you struggle with low dopamine then I would definitely recommend trying this. It seems like maybe I need it the most but just need to start off smaller because 8 mg made me feel kryptonited. Additionally, zinc is a fairly easy nutrition to obtain from food. The fact that dysfunction of the dopamine transporter is involved in the pathogenesis of A plausible explanation is that 5-10% of people of sensitive to supplements and can have strong reactions. In mice, cocaine decreased striatal vesicular Zn2+ and They do this in part by reversing the DAT, so that rather than shuttling dopamine back into the neuron, it transports dopamine out of the neuron. This was pretty interesting because both magnesium and zinc affect gaba level and NDMA receptor here are the effects i had: -bone growth (grew taller) this is what happen to me, I take zinc gluconate 30mg (elemental) 4 hour before sleep, and I've got rush of adrenaline before sleep and couldn't sleep at all, every time I drink I pee it out just like 3 minute after. May in my case would be worth trying aswell, one of the most basic approeches. So I tried it out as I felt myself shutting down / dissociating and it actually worked! Anyone else tried this and noticed it helps? So now I take it Zinc (Which type of zinc should I take?) Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Careers Press. Mineral supplements, including the one OP shared, denote the elemental Zinc amount. Zinc should not be taken with other metal supplements like iron as they compete for absorption. Watch his video on dopamine and the analogy of the tidal wave pool. Or check it out in Iron is a co-factor in the synthesis of both norepinephrine and dopamine. Creatine: Study Link I tried 100mg of Zinc per day and within a few days I felt mildly stimulated like I'm on Sunifiram all day. They're nothing like stimulants in practice. The study is specifically with cocaine addicted mice, and basically zinc made The only 'media' I consume is in the way of social media on Reddit. I take zinc, magnesium, and glycine at night anyways so I Copper is only supplemented alongside zinc sometimes as zinc depletes copper in your body, Not to be pedantic, but zinc inhibits absorption of copper, it does not deplete the body's store of copper. Make sure you are covered with basic stuff too such as magnesium, zinc, b vitamins and d vitamin. g. Boron / Zinc / Tribulus for a slight testosterone increase (cycling boron and Tribulus) Magnesium Glycinate High dose of B12 Korean red ginseng (Cycled) Coffee (Cycled) Modafinil (Cycled) Lion's mane at high dosage, constantly during the day (cycled) Probiotics strains promoting dopamine and serotonin synthesis Copper is an antagonist of zinc and can cause a host of problems, especially for men since we're supposed to be Zinc dominant because Zinc plays a huge role in the production of testosterone, the inhibition of prolactin which suppresses dopamine and prolactin, and also the production of dopamine. Introduction. Makes me feel sharp for hours. The issue is tolerance changing the regulation of those dopamine receptors. Example: 50mg of Zinc Gluconate is actually 7mg elemental zinc. The 4 supplements are: Zinc, Creatine, NAC and Fish Oil Zinc: Study Link. Zinc is an essential trace element required by all organisms for various biological processes. B vitamins on the other side Helps Produce Dopamine. Does Zinc L-carnosine increases serotonin? Fatigue can be caused through multiple pathways: 1- Lower norepinephrine due to low Dopamine Beta Hydroxylase activity (a Copper enzime that tranaforms dopamine into norepinephrine). Normal people do not have high levels of cell zinc saturation. Decided to run to the Walmart and grab those. Disruptions in this specific interplay might be a cause of a pathological depressive state, and restoring balance and cooperation between those systems might be key to a successful form Does anyone know why stopping magnesium and zinc makes my brain fog feel better even though at one point using them made my tingling and brain fog at the advice of people on Twitter, Reddit etc If you get enough tubers, coffee I've seen the threads about taking 5htp with L tyrosine to prevent dopamine depletion, Was once treated for depression before my AuAdhd diagnosis. Serotonin: 5htp and L-tryptophan. The cold was getting better but my muscles where not. But even one dose now completely obliterates my dopamine system. Hi, we likely have the same issue. Seems to be really common for those with slow COMT based on what people are saying on reddit. But i would also advice against taking so much zinc in one dose. to get 20 mg of zinc can take upwards of 200 mgs of zinc supplements and if your doing that then throw in some copper According to this study, high dose Zinc supplementation (60ppm in drinking water, equal to 60mg per day in humans) does not change brain zinc at all: . The question is asking how do people get high when the body doesn't have the resources to provide the dopamine creation the drug triggers. _____ ADEQUATE ZINC LEVEL-Definite but not strongly unpleasant taste is noted before swallowing Zinc inhibits prolactin in the CNS, increases thyroid hormone activity and antagonizes NMDA receptors. RDA for men is 11mg. true. I think zinc acutely reducing cortisol to be a much more helpful and important factor in deciding to take Zn alongside stims like dex. I cut one 25mg pill to half and take a half every day, that’s all you need. DBM normally converts dopamine to norepinephrine. Its general actions are well reviewed, as briefly described in this paper and several excellent reviews (Marger et al. Zinc increases dopamine. My mother took it (because her doctor told her to) when she was dying from cirrhosis of the liver. Finally zinc also antagonizes copper. If estrogen is driven too low in males, libido and erection quality suffer. Successful antidepressant treatment can raise zinc levels. Cocaine appears to lower your zinc levels, that's why supplementing seems to help. D of 80. Ever since starting zinc supplementation I've started to wonder if I haven't been deficient almost my whole life because I've done a complete 180 when it comes to my anxiety and depression symptoms. The bioavaliabilty of zinc supplements is very low, as little as in the teens depending on type, and the all vary. RDA of zinc is 11mg, no one needs that much zinc. Supplementing zinc has made me feel great. Get app Get the Reddit app Log In Log in to Reddit. But once I pass the dopamine withdrawal of stopping my meds or supplements, I feel my personality come back, I feel so much more crazy and wild thinking and more quick witted. r Here are some reasons why zinc could work for social anxiety or hesitation: Zinc deficiency and anxiety: Low levels of zinc have been linked to symptoms of depression and anxiety. In a U. Not sure if they will help but worth a shot and taking these daily should support immune, I am experiencing antidepressant induced tinnitus and trying to avoid supplements that boost serotonin. But vitamin c and tyrosine. On a supplemental level take l-tyrosine for dopamine and 5-htp for serotonin. An increased DA level in the hippocampus of mouse offspring following prenatal exposure to zinc oxide nanoparticles was observed . Amen low dopamine is related to attention Anyways, stick with those precursors and then stay off of tv and your phone. Magnesium Glycinate - 400-600mg / day split over day. I don’t get how people actually benefit from it. Copper supplementation is necessary to prevent deficiency when supplementing high dose zinc, however at 30mg zinc per day you should be fine. Increased dopamine receptor density is not I’m easily addicted and seek dopamine. However, it wasn't until recently that scientists examined the compounds in the plant and discovered that many of them can reduce prolactin as much as dopamine itself (7). I had a similar experience with zinc picolinate though, it seemed I was getting too much zinc. It's the most direct pathway to produce catecholamines in the central nervous system, importantly bypassing peripheral dopamine synthesis. Maybe your getting a bump in some of the more stimulating ones. I know this is mthfr Reddit, which I do have, but does anyone have slow comt, ADD, and addicted to dopamine increasing things L-Tyrosine is my goto/must have for keeping my Dopamine reward system working optimally. I feel the grasp of reddit daily to be honest, I just love to read about I started taking a zinc+copper supplement and felt more energy at first, but quickly become overloaded in copper and became extremely irritable. Reply reply More posts you may like r/Nootropics. That's the whole point of it. It's actually not necessarily paradoxical - Zinc potentiates dopamine release by Amphetamine (through DAT allosteric modulation), but at the same time, it might also decrease dopamine production (through inhibition of iron binding to TH). In hindsight I might have fared better on TCAs or MAOIs. From what I read, methylation is involved in breaking down dopamine through the COMT pathway, but it doesn't seem to be involved in dopamine production from tyrosine. EDIT: Just found. Does the zinc you used contain vitamin B6 also, by the way? Vitex Agnus Castus, also known as Chaste berry, has long been used as a treatment for sexual disorders and insufficiency. Dopamine agonists can make people drowsy, almost narcoleptic. 5 grams. Although zinc is widely prometed as a life changer mineral, it's still a heavy metal and when taken in excess; you won't pee out the unnecessary amount like the case in Vitamin C. Zinc levels and the zinc receptor are altered by classic antidepressant treatment, which indicates possible reciprocity between the monoaminergic system and zinc signalling. The end result is more neurotransmitters exactly where you want them and not where you 66 votes, 75 comments. 28 votes, 71 comments. Is it the best form of zinc I should be taking? I heard it’s the most absorbable form of Zinc The human dopamine transporter (hDAT) contains a high affinity extracellular zinc binding site which, upon zinc binding, inhibits dopamine reuptake and amplifies amphetamine Zinc dose - that's a tough one because it is possible to overdose. Zinc deficiency represents one of the most-recognized micronutrient deficiencies linked to ADHD symptoms. Zinc is involved in the synthesis, storage, and release of neurotransmitters, including dopamine, which regulates mood, motivation, and reward. This way, simple things will give you the dopamine boost. Zinc can potentially affect dopamine transmission/synthesis by depleting copper. With the popularity of Vitamin C and Zinc as supplements, I would say Zinc overload/toxicity and Copper deficiency are probably more common than Copper toxicity. I stay well away from current affairs. Nor does zinc do anything for ADHD if you are not deficient in the mineral. I was taking 50mg of elemental Zinc for the last 2 years. like not nearly enough. The RDA for Zinc is 11mg daily for adults, and the RDA for Zinc is 0. Dopamine: Mucuna pruriens. Adult men: 11 mg Adult women: 8 mg I’m looking for supplement recommendations to help reduce dopamine addiction and the need for stimulus from And I’m curious because I’ve had an issue with zinc the past few Only social media I use is reddit and I signed up 2 years ago. Vitamin B6 Welcome to r/science!This is a heavily moderated subreddit in order to keep the discussion on science. As a neurotransmitter, dopamine enables the mind and muscle to work together, increasing the benefits that occur from weightlifting. All this is good, but the problem is that while zinc is the signal for producing metallothioneins, these proteins bind to copper better than they do to zinc. I don't know why these self-help pseudo-science blogs call it a I became so sensitive to Zinc that even on a completely filled stomach, the Zinc from a Multivitamin (10mg) makes me vomit violently. Or check it out in the app stores Inositol literally upregulates both dopamine and serotonin. Or check it out in the app stores More dopamine = more libido, more serotonin = more libido. Just make sure you drink it before the meeting, and if coffee makes you anxious, yerba mate is better (you could probably buy it at some "healthy-ish" store). This community is focused on neuroscience research of how autism, ADHD, OCD, schizophrenia Since zinc is necessary in the metabolism of melatonin, it is strongly implied in the regulation of dopamine (zinc is therefore considered a dopamine reuptake inhibitor). These epithelial cells shed every 5-6 days, and the metallothioneins with their bound excess zinc are shed too, and excreted in feces. Log In / Sign Up; Advertise on Reddit; I suspect it may be a lack of dopamine since I'm not actually depressed, ashwaganda, inositol, 5htp, zinc, Vit B`s, NAC. Might also want to look at r/nootropics for other supplements that boost mood such as ginseng, ginkgo Balboa, Maca etc. In general, it was like drinking too much caffeine. Ive taken zinc citrate at 25 mg/day for about 2 months, I was doing 50 mg but I was having nausea immediately after taking it so I cut back to 25. nih. repeated tasks etsWhich some studies were ameliorated with glycine, arginine, zinc, and creatine ( I can't find the study at the moment)My current stack is I have no clue why all manufacturers seem to be replacing zinc pyrithione with piroctone olamine! I hope it is not due to a potential change of the regulation in EU. So I leveled down to zinc from my stack that is causing the anxiety, but interestingly Ive been taking it for 1 month and it helped me with my anxiety, and then some days ago I took it and I worsen my anxiety, but I noticed without taking zinc my anxiety has improved. . Take 1g a day. 1g of Yerba mate contains around 8-10mg of caffeine. nlm. The only downside I've got is that it seems to *raise histamine (I've already have high histamine levels) and I get itchy scalp. I haven’t had any sleep issues with it. Title: "Effects of Long-term Acetyl-L-carnitine Administration in Rats: I. If both occur at the same time, though, Amphetamine could deplete dopamine stores faster. Zinc and iron blood levels of at least 100. Copper and Zinc are Antagonists, a lot of stress and depression can deplete Zinc. So, a 50mg tab of zinc gluconate would be roughly 7mg of elemental zinc. Perhaps it's placebo, or maybe I've been Zinc deficient -- or maybe Zinc is a top secret Nootropic disguised as a useless mineral supplement? The proposed short term high zinc intake system is based on studies conducted on normal people. It is also anecdotally reported to give people vivid dreams and a significant increase in appetite, 2 effects commonly seen in people who use dopamine agonists. Zinc promotes gaba production (aswell as glycine) this competes with dopamine and can lower dopamine causing irritability and anger if you are already low! You can try to offset this by taking tyrosine which increases dopamine! A common long term side effect for ashwaganda is reported to be anhedonia. What others do YOU know? Little educational post attempt here, let's all High zinc supplements are well known to deplete copper, enough that zinc is used as a treatment for excess copper. Same thing happens when you constantly hit that dopamine and eventually it down regulates. On a personal psychological note you should get into eastern philosophy particularly Buddhism. Due to its critical functions, DA expression levels in the brain are tightly controlled, with one important and rate There are a number of ways zinc does this, but some of these include: •prevents your brain from becoming overexcited at NMDA receptors •helps create/regulate serotonin, GABA, dopamine •increases BDNF According to Trudy Scott, the zinc taste test can help determine if Like zinc gluconate is 14. Desire (dopamine) is the root of all suffering. Magnesium glycinate on the other hand actually caused some anxiety. I read that max zinc per day is 30-40mg Zinc levels and zinc supplementation seems to be a big thing in nutritional psychiatry. B-vitamins, zinc, choline, creatine, vitamin D) and I’ve also been warned many many times about “copper toxicity” and even told on Reddit that although my copper levels were low across any and all blood and hair tests, Zinc can act as a dopamine reuptake inhibitor, increasing dopamine, which can cause anxiety is some people. I got my levels back a few weeks ago and they are 10 umol/L (or 65 ug/dL). For example, a Harvard article titled "Nutrition's dynamic duos" discusses the effects of high amounts of zinc causing copper deficiency so they recommend adding copper to zinc supplements. The only one that I know of is extract from Nightshade plant. Basically being super healthy, will do more then any "T boosing" supplement. A dopamine releasing agent (DRA) is a type of drug which induces the release of dopamine in the body and/or brain. Using co-forms of zinc that have other uses in the body like zinc sulfate, (which you are) and zinc glycinate instead of zinc picolinate or zinc gluconate is superior as picolinate & gluconate are worthless binding agents once cleaved from the The dopamine transporter is regulated by zinc (Zn2+), which directly interacts with the transporter protein as a potent non-competitive blocker of substrate translocation (dopamine transport inward and outward). Zinc can lower estrogen. Furthermore, zinc supplementation is well known to boost testosterone. The optimal ratio is said to be anywhere between 8:1 Zinc:Copper to 15:1 Zinc:Copper; there is no universal agreement on the optimal ratio. Zinc is an important cofactor for metabolism relevant to neurotransmitters, prostaglandins, and melatonin, and indirectly affects dopamine metabolism. Zinc is very efficient at depleting copper. AlphaGPC is the one for Acetylcholine, but it does have an unfortunate side-effect because if you take it every day, it feeds some “bad” bacteria in your gut Zinc has completely changed my life. Dopamine reuptake inhibitors, such as cocaine, block the influx of dopamine (intake of dopamine from the synapse back into the neuron. Dopamine affects libido, which Summary: Bromantane increases dopamine synthesis, balances excitatory and inhibitory neural networks, and increases neurotrophins by reducing neuroinflammation through epigenetic mechanisms. I take plenty of both zinc and copper too. possible its the zinc supplement reducing supply of tyrosine. So basically if you remove the need to make creatine, the methionine cycle can turn faster, which in turn turns the folate cycle faster, Zinc, riboflavin, green tea all inhibit 5ar, Well, dopamine plays a role in attention, learning, memory, and reward so yeah everybody is "addicted" to dopamine. https://www. This is without accounting for excess consumption of Vit C and Zinc. I normally have severe social anxiety and symptoms of CPTSD. Take it with your adderall for a better peak and easier comedown, or take it as the last adderall is wearing off Zinc increase dopamine and testosterone and both can increase arousal even in non deficient people . Can attest myself after several years on and off. Abstract: "Acetyl-L-carnitine (ALCAR) is the acetyl ester of carnitine that has been reported to be . So I read online zinc improves dopamine processing in Autism because it balances copper which is elevated in ASD. Guess I eat enough protein to have my tyrosine needs covered already. There’s a couple groups that are promoting copper due to deficiencies. Log In I literally cannot release or feel dopamine (through the D2 receptors Get the Reddit app Scan this QR code to download the app now. In addition to that, not all of it absorbed. Copper is Zinc supplementation when deficient has been linked to significant relieve of depressive symptoms in depression and can increase cognitive functioning. On a side note, I’ve tried zinc for many years and always had to come off because it would cause side effects. Zinc plays a big role in neurotransmitter synthesis. I took a few weeks off it and supplemented with zinc and copper and eventually felt normal. If a brand is doing otherwise, it is a really weird brand. 1996) and human findings suggest involvement of zinc deficiency in hyperactivity. Dopa, a precursor of dopamine is oxidatively produced from tyrosine by the copper enzyme tyrosinase. I took 8 mg and it was way too strong for me. I would strongly recommend trying those before trying SAM-e. The dopamine transporter (DAT), a membrane protein specifically expressed by dopaminergic neurons and mediating the action of psychostimulants and dopaminergic neurotoxins, is regulated by Zn(2+) which directly interacts with the protein. B-vitamins generally increase methylation levels (the outlier here would be B3) and, in turn, raise monoamine levels (e. 2. 8K subscribers in the autismgirls community. Generally speaking, dopamine agonists and dopamine reuptake inhibitors don't have as much overlap in their prescribing indications as you'd expect. I would say 15-20mg/day wouldn't hurt - but I'd back that up with getting your blood zinc checked semi regularly to be sure. The link is strong enough that the degree of zinc deficency can accurately predict the severity of depression. FB, Instagram, Plasma noradrenaline and dopamine concentrations were increased by 530% and by 250% respectively, zinc and magnesium Omega 3 Making work into a game. I also eat meat and try to be healthy, but now I'm realizing I had 30 mg of zinc daily for at least 2 months and no added copper, except in my diet to balance it. I was affraid I had got too much copper from taking beef liver for months and had 15mg of zinc in my prenatal that I'm still taking and 15mg seperately. Anyway, although it might be fine to use short-term in a targeted Specific to ADHD, the dopamine transporter has a zinc binding site that blocks transport (Lepping and Huber 2010). View community ranking In the Top 1% of largest communities on Reddit. Task switching is easier, motivation, attention and alertness is higher. I thought I'd hit the jackpot with St Johns Wort, until I found some articles about how it's quite a strong Norepinephrine inhibitor (by way of impairing the DBH gene) DAMN IT! Get app Get the Reddit app Log In Log in to Reddit. Especially managing stress. No major changes. Somebody here on reddit mentioned that, but I couldn't find any info. By letting go of attachments you are exiting the hamster wheel of dopamine. Stop doing those first and your dopamine will come back and cortisol will lower. Zinc defiency can also cause brain fog and ADHD Dopamine-β-Hydroxylase has 2 cofactors copper and Vit C. It got rid of my anhedonia, depression, anxiety and what I thought was permanent sexual dysfunction caused by SSRI treatment. Excess copper converts your dopamine to norepinephrine, I felt psychotic and it took a couple of days supplementing zinc Zinc plays a large role in how we react to stress and deficiency is linked to depression. I’ve done this and it’s worked great but I was wondering what are some other ways you can increase your dopamine naturally ? I’m really struggling to focus these days even though I’m on Zinc citrate is also good. I'm extremely sensitive to increases in dopamine because of some weird neurological problems I have. ZMA is not really a good product. Zinc is also important to thyroid. The original formula consists of mag aspartate, and aspartate is excitatory. Look up the content of elemental (actual) zinc in whatever product you are taking. Drugs like ecstasy or molly blow all your dopamine levels and take many days to replenish. B6 is necessary to convert tyrosine into dopamine and tryptophan into serotonin, via reactions that occur in the brain. Apparently (too much) zinc can affect brain dopamine binding, you can research this by googling zinc dopamine. conformational change). gov/pubmed/19000913?dopt=Abstract The possible mechanism behind this effect would be the fact that picolinic acid is Dopamine beta-monooxygenase (DBM) inhibitor. Not only is dopamine important for muscle building benefits, but it can also counteract depression. 20 mg of zinc is very little. When you quit one drug you substitute it for another. Many people report a loss of effects after consecutive days of dosing. I just joined this group and see that when ppl post, they just say they're taking x amount of zinc but never say in what form. Was given an SSRI, worked a little then I hit another slump. Evidently Bacopa acts similarly to NAC and I felt so shitty I almost tried to find a therapist. but I still could enjoy comedy on TV or youtube. “In noradrenergic neurons, Cu is needed for activity of dopamine-β-hydroxylase (DBH), which converts dopamine to norepinephrine and is required for catecholamine balance” “Cu is required for myelination of neurons [ 13 ], and it influences synaptic transmission by modulating functions of GABA and NMDA receptors, as well as voltage-gated Ca2+ channels” Zinc. Sleep well, eat well, go out in the sun and exercise. This was right at the I take 50mg of Zinc Picolinate a Day, it replace the amino acid chelate zinc I used to take. Zinc can cause a one-time spike in dopamine levels if you've been mildly Hi folks, I've tried Polygala and I like it since it helps with overthinking and mild anxiety. In case supplementing zinc to compensate for possible effects of histidine supplementation, be aware zinc can deplete copper if overdone, such as 50 mg/d zinc long term. The results of the present study indicate that zinc supplementation together with SSRIs antidepressant drug improves major depressive disorders more effectively in patients with placebo plus antidepressants (SSRIs). Autistics need serotonin, ADHD need dopamine, so I guess I wasn't doing myself any favor. hydrophobic), whereas for dopamine re-uptake inhibitors it is enthalpy-driven (i. I had via blood test confirming that my zinc levels were on the low end and my doctor wants me to get mine up. The recommended dietary amount (RDA) is as follows: . That's how we evolved. In essence, there really is known storage of copper within the body as evidenced by rapid depletion with copper-restricted diets. John's Wort. Recently I made the mistake of trying NAC and Bacopa back to back. In all honesty, it probably only makes a difference if you're a regular user. Your symptoms are possibly what people refer to as "overmethylation". Background Dopamine (DA) is a neurotransmitter that plays roles in movement, cognition, attention, and reward responses, and deficient DA signaling is associated with the progression of a number of neurological diseases, such as Parkinson’s disease. Recently heard a Psychiatrist say serotonin lowers down dopamine levels. Hold about a teaspoon of (zinc sulfate) in your mouth for about 10 seconds. Zinc gluconate has been much more effective for me. Still, both are significantly different than what is in the brand you have been taking. Herein, we report a Zinc is a surprisingly effective supplement as well, and actually is a subtle dopamine re-uptake inhibitor. I'm a bit confused about the link between the two. Zinc can also lower estrogen. Vitamin B6 P5P form - Required for both serotonin and dopamine Zinc Picolinate - but be careful - you can take too much. Low DHT = low libido. and I can tell you zinc 25 mg gave me the calms and lowered my heart rate. Your common SSRI that is probably the most effective is St. This culminated in at the end of 2023 I caught a cold that lasted for almost 2 months and I took that zinc every day (plus antibiotic Doxycycline). I think It's a combination of lack of sleep plus depression. The appropriate amount of zinc you should be getting each day generally depends on your age and gender. I suggest the glycinate form. However, when people talk about undermethylators and overmethylators, they associate undermethylators with low dopamine. 35% elemental zinc by wright. 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